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  3. Mosavar Farahani

  • Dr Mosavar Farahani has joined University of Northampton as a senior Lecturer. Mosavar has over 16 years’ experience working as NHS Scientist and Honorary lecturer.

    Prior to joining University of Northampton, Mosavar worked in the NHS for 17 years as NHS Scientist at Royal Liverpool University Hospital. Mosavar worked in the department of Molecular Genetics, which is part of the Haematology-Oncology Diagnostics Service (HODS).

    • SLS3027 Haematology and transfusion science, Module Lead
    • SLSM012 Molecular Medicine
    • SLS1019 Introduction to Microbiology
    • SLS1021 Fundamentals of Immunology
    • SLS3002 Integrated Medical Genetics
    • SLS2010 Health and Disease

  • Mosavar’s research area of expertise is exosomal microRNA in haematological malignancies. Mosavar is interested in the role of miRNAs involved in cancer as miRNAs could represent a potential non-invasive diagnostic and prognostic biomarkers.

    • Giannoudis A, Clarke K, Zakaria R, Vareslija D, Farahani M, Rainbow L, Platt-Higgins A, Ruthven S, Brougham KA, Rudland PS, Jenkinson MD, Young LS, Falciani F, Palmieri C. A novel panel of differentially-expressed microRNAs in breast cancer brain metastasis may predict patient survival. Sci Rep. 2019 Dec 6;9(1):18518
    • Farahani M, Rubbi C, Luning L, Slupsky J, Kalakonda N. CLL derived exosomes are selectively enriched in miR-202 and modulate the transcriptome and behaviour of recipient cells.  PLoS ONE (2015), 10(10): e0141429.
    • Lin K, Farahani M, Yang Y, Johnson GG, Oates M, Atherton M, Douglas A, Kalakonda N, Pettitt AR. Loss of MIR15A and MIR16-1 at 13q14 is associated with increased TP53 mRNA, de-repression of BCL2 and adverse outcome in chronic lymphocytic leukaemia. Br J Haematol. 2014 Nov; 167(3):346-55
    • Abrams ST, Lakum T, Lin K, Jones GM, Treweeke AT, Farahani M, Hughes M, Zuzel M, Slupsky JR. B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase C beta II.  Blood. 2007 Feb 1; 109(3):1193-201
    • Farahani M, Treweeke AT, Toh CH, Zuzel M, Cawley JC & Chen HJ.  Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells. Leukemia.  2005, 19(4):524-30
    • Pateromichelakis S, Farahani M, Phillips E, Partridge M. Molecular analysis of paired tumours: Time to start treating the field. Oral Oncology (2005) 41, 916–926
    • Hardy E, Farahani M, Hall IP.  Regulation of histamine H1 receptor coupling by dexamethasone in human cultured airway smooth muscle.  Br. J. Pharmacol. 1996; 118: 1079-1084