Lee’s research is focused on employing cellular and molecular genetic strategies to address how the host immune system responds to pathogens and cancer. The aim of this work is to increase our understanding of human health and disease and develop rational therapeutic approaches to harness the exquisite specificity and sensitivity of the immune system.
Key areas of research are:
- Copy number variation of immunity genes
- Tumour immunology and the development of cancer immunotherapy
Lee collaborates locally, nationally and internationally to advance his research agenda and has worked on Cancer Research UK, Medical Research Council and Wellcome Trust funded projects. He is a regular reviewer for a number of academic journals including Human Immunology, Blood, PLOSone and PLOS Genetics. He has published in high impact journals including Blood, American Journal of Human Genetics and the American Journal of Pathology and is an occasional reviewer for major funding bodies.
Post Graduate Supervision:
- Nermin Albalbeisi; Characterising the Role of the Calcium-dependent Citrullinating Enzyme Peptidyl Arginine Deiminase 2 in Ovarian Cancer (completed)
- Adam Gregory; The prevalence and persistence of antimicrobial resistance markers in anaerobic digestion plants.
- Amber Hameed; Characterisation of the lipooligosaccharide (LOS) biosynthesis gene clusters in Campylobacter species. (Completed)
- Michael Naidoo; The role of Dystophin in Low grade glioma
- David Young; Evolutionary genetic dissection of Fc receptors for IgG antibodies.
- Guido Di Martino; Welfare issues in Italian heavy pig production. (Completed)
- Mett Smart; Bacterial Growth within Endoscope Channels between Reprocessing and Use: a scientific approach
- Faz Sultana; Rapid Analysis of non-tubercular mycobacteria species (NTM) using PCR and End-Point analysis
- Lewis Waterfield; Response of Streptococcus pneumoniae to metal and oxidative stresses.
- Leanne Jones; Investigating a role for dystrophin in the tumourigenesis of head and neck cancer.
- Amanda Ash; Cell migration in the neuropathophysiology of Duchenne muscular dystrophy
- Saul Cuttell; Effects of different forms of eccentric exercise and cryotherapy on exercise induced muscle damage and the repeat bout effect
- Izzat Al- Rayahi; Role of Properdin in Tumour Growth and Cell Recruitment (completed)
- Rafah-al-Zubeidi; Obesity as a modulator of tumour microenvironment and anti- tumour responses in a mouse model (completed)