Photo of Dr. Alexander Lehner

Dr. Alexander Lehner

  • Job title: Senior Lecturer in Human Nutrition
  • Department: Sports, Exercise & Life Sciences

General information

  • PhD Biological and Biomedical Sciences; Nutrition and Health Sciences
  • BA Psychology
  • Certificate in Postgraduate Research Supervision in the UK

Teaching

Module Leader

Undergraduate

  • HLS1003 - Molecular Biology of the Cell
  • HLS1016 - Introduction to Human Nutrition
  • HLS2006 - Nutritional Perspective of Health and Disease
  • HLS2007 - Processes of Life: Biochemistry
  • HLS3005 - Communities and Nutrition

Postgraduate

  • HLSM102 - Nutrition in a Global Context

Other Modules Contributed to

  • HLS1006 - Concepts of Health  
  • HLS1007 - Health over the Lifespan
  • HLS1012 - Integrated Physiology
  • HLS2012 - Health in Later Life  
  • HLS2013 - Body Matters
  • HLS2016 - Research Methods    
  • HLS3007 - Health Risk and Environment  
  • HLS3009 - Immunology
  • HLS3011 - Researching Populations Health  
  • HLS3013 - Ethical Issues in Health     
  • HLS3014 - Integrated perspectives in Health and Disease
  • HLS3016 - Sport and Exercise Nutrition  
  • HLS4001 - Human Biology Dissertation  
  • HLS4005 - Health Studies Dissertation
  • NPR1002 - Life Sciences for Healthcare Professionals
  • HLSM100 - Bioethics

Supervisor to PhD Candidate in the School of Health

Kennedy Mdaki:
Characterisation of uncoupling via inactivation of mitochondrial aconitase

Supervisor to PhD Candidate in the School of Science and Technology

Yonggang Duan (Completed 2008):
Novel crosslinked collagen matrix: assessment for efficacy as wound dressing

Research

Dr Lehner's laboratory research attempts to answer questions at the level of the mitochondrion with regard to energy efficiency and the regulation and dysregulation of oxidative stress.  A key question behind his studies is how dietary components, both nutrients and contaminants, especially metals, affect mitochondrial function to result in homeostasis or disease.  He is currently elucidating a new model of energy regulation and exploring how it ties together specifically the chronic diseases: Obesity, Diabetes Mellitus, Cardiovascular Disease, Cancer and Alzheimer's Disease.  The hypothesis underlying the model is that the central nervous system is used by the mitochondria to coordinate all energy related processes in the human body.

Key Collaborations with the University of Nottingham in the UK and the Buck Institute for Research on Aging in the USA, have allowed Dr Lehner to work with international leaders in the field, from Foetal Programming to Geroscience.

He is also now applying his understanding of bioenergetics regulation to the development of novel collagen matrices for use in bandages to facilitate more efficient wound healing. He has additionally, in the past worked on a large clinical trial to determine the effect of Vitamin E on exercise induced oxidative stress in relation to CVD, explored the effects of oxidation on specific enzymes, and have investigated how certain proteins regulate mRNA export from the nucleus.

Outside of the laboratory Dr Lehner completed a study which evaluated the effectiveness of government funded school based interventions on children's eating behaviour, including drama based interventions.  The study included investigating dietary intakes and assessing body composition, as well as the children's dietary understanding.  As a Result of this study and his association with Benevolent Ballet, Dr Lehner is now pursuing further interdisciplinary research to elucidate a new model of Empathic Engagement. This model connects the principles of behaviour modification with the principles of cellular and organismal energy metabolism to develop a unified and applicable theory of bioenergetics.

Publications

Jump to: 2016 | 2015 | 2013 | 2012 | 2007 | 2005

2016

  1. Khatri, R., Logan, P., Kay, A. D. and Lehner, A. N. (2016) Does splinting the upper limb improve the quality of life and functional independence of stroke survivors? British Journal of Occupational Therapy. 79(8,supp), p. 42. 0308-0226.
  2. Poursamar, S. A., Hatami, J., Lehner, A. N., da Silva, C. L., Ferreira, F. C. and Antunes, A. P. M. (2016) Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering. International Journal of Polymeric Materials and Polymeric Biomaterials. 65(6), pp. 315-322. 0091-4037.
  3. Poursamar, S. A., Lehner, A. N., Azami, M., Ebrahimi-Barough, S., Samadikuchaksaraei, A. and Antunes, A. P. M. (2016) The effects of crosslinkers on physical, mechanical, and cytotoxic properties of gelatin sponge prepared via in-situ gas foaming method as a tissue engineering scaffold. Materials Science and Engineering: C. 63, pp. 1-9. 0928-4931.

2015

  1. Poursamar, S. A., Hatami, J., Lehner, A. N., da Silva, C., Ferreira, F. and Antunes, A. P. M. (2015) Gelatin porous scaffolds fabricated using a modified gas foaming technique: Characterisation and cytotoxicity assessment. Materials Science and Engineering: C. 48, pp. 63-70. 0928-4931.
  2. Samet, L., McCormick, W. D. and Lehner, A. N. (2015) The use of a test battery to ascertain efficacy of herbal supplements in rats. Seminar Presentation presented to: 4th Postgraduate Research Symposium, Moulton College, Northampton, 11 December 2015.

2013

  1. Khatri, R., Logan, P., Kay, A. D. and Lehner, A. N. (2013) A national survey to evaluate current splinting practice for stroke survivors. Paper presented to: 37th Annual Conference and Exhibition of the College of Occupational Therapists 2013, Glasgow, UK, 18-20 June 2013. (Unpublished)
  2. Poursamar, A., Lehner, A. N. and Antunes, A. P. M. (2013) Optimized gas foaming procedure to prepare gelatin scaffolds for wound management. Poster presented to: XXXII Congress of the International Union of Leather Technologists and Chemists Societies (IULTCS), Istanbul, Turkey, 29-31 May 2013. (Unpublished)

2012

  1. Engeham, S., Mdaki, K., Jewell, K., Austin, R., Lehner, A. N. and Langley-Evans, S. C. (2012) Mitochondrial respiration is decreased in rat kidney following fetal exposure to a maternal low-protein diet. Journal of Nutrition and Metabolism. 2012, pp. 1-10. 2090-0724.
  2. Poursamar, A., Lehner, A. N. and Antunes, A. P. M. (2012) Optimising gas foaming to obtain highly porous gelatin scaffolds. Poster presented to: 3rd Tissue Engineering and Regenerative Medicine (TERMIS) World Congress, Vienna, Austria, 05-08 September 2012. (Unpublished)
  3. Poursamar, A., Lehner, A. N. and Antunes, A. P. M. (2012) Porous gelatin scaffold mechanical behaviour under cyclic load as a function of water content. In: Fernandes, P., Folgado, J. and Silva, M. (eds.) Journal of Biomechanics Special Issue: Proceedings of ESB2012 - 18th Congress of the European Society of Biomechanics, Volume 45, Supplement 1 (2012). Online: Elsevier. 0021-9290. S49. [Journal of Biomechanics, Vol. 45, Supplement 1]

2007

  1. Apponi, L. H., Kelly, S. M., Harreman, M. T., Lehner, A. N., Corbett, A. H. and Valentini, S. R. (2007) An interaction between two RNA binding proteins, Nab2 and Pub1, links mRNA processing/export and mRNA stability. Molecular and Cellular Biology. 27(18), pp. 6569-6579. 0270-7306.

2005

  1. Karabina, S.-A. P., Lehner, A. N., Frank, E., Parthasarathy, S. and Santanam, N. (2005) Oxidative inactivation of paraoxonase - implications in diabetes mellitus and atherosclerosis. Biochimica et Biophysica Acta (BBA) - General Subjects. 1725(2), pp. 213-221. 0304-4165.
This list was generated from NECTAR on Tue May 22 16:17:11 2018 BST.

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