Photo of Dr. Stuart Raleigh

Dr. Stuart Raleigh

  • Job title: Reader in Molecular Biology
  • Department: Sports, Exercise & Life Sciences

General information

Stuart is a biochemist who graduated from the University of York in 1991 before starting his research career at St Bartholomew's Hospital Medical College in London the following year. In 1998, he received his PhD for conducting research into variant Cytochrome P450s (CYPs) that could metabolise novel anticancer prodrugs under hypoxic conditions. After postdoctoral work at the University of Leicester's School of Medicine, he moved to the Department of Cardiovascular Sciences (2002–2005) where he investigated the role of genetic variability as a risk factor for hypertension and heart disease.

In 2005, Stuart was appointed as Lecturer in human biology at the University of Northampton. In 2006, he was promoted to Senior Lecturer and in November 2011 he became a Reader in Molecular Biology within the University’s Division of Sport, Exercise and Life Sciences. His research interests continue to focus on genetics, epigenetics and biochemical mechanisms of disease. He is specifically interested in identifying genetic variants that influence the risk of musculoskeletal soft tissue pathologies, such as tendinopathy and ligament ruptures. He is also initiating work on the link between miRNA expression and various age-related chronic diseases.

Stuart is a Member of the British Society for Genetic Medicine, the Biochemical Society and he currently leads the University of Northampton’s Centre for Physical Activity and Chronic Disease (PACD). He is a Fellow of the Higher Education Academy (HEA) and he is Section Editor (Genomics theme) for the Journal of Sports Science and Medicine.

Teaching

Undergraduate contributions:

  • Single and Joint Honours BSc Human Bioscience (course leader, 2006-2010)
  • Single and Joint Honours BSc Sport and Exercise Science
  • Single and Joint Honours BSc Biology

Undergraduate module contributions:

  • Genes and Genomics (SLS2001)
  • Integrated Medical Genetics (SLS3002)
  • Health and Disease 2 (SLS2010)
  • Bioscience Research Methods (SLS2013)
  • Human Bioscience Dissertations, (SLS4003)
  • Biochemistry and Cell Biology (SLS1013)
  • Health, Risk and the Environment (SLS3001)
  • Research for Practice (FDN 008)

Research

Projects (2010-current):

  • Preliminary studies into exercise induced gene expression in two different populations, 2014. University award
  • Human gene copy number variants and epigenetics as risk factors for musculoskeletal pathology, with an emphasis on Achilles tendon disorders, 2012. Rosetrees Medical Trust
  • Epigenetics as risk factors for musculoskeletal pathology, with an emphasis on Achilles tendon disorders, 2012. University Award
  • Gene variants that predispose to soft tissue musculoskeletal pathology, University of Northampton, 2011. RAE Development fund
  • Gene variants that predispose South African and Australian populations to ACL rupture, award number 09851/B, 2009. Leverhulme Trust

Publications

Jump to: 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2005 | 2004 | 2000 | 1999 | 1998 | 1993

2016

  1. Heffernan, S. M., Kilduff, L. P., Erskine, R. M., Day, S. H., Mcphee, J. S., McMahon, G. E., Stebbings, G. K., Neale, J. P. H., Lockey, S. J., Ribbans, W. J., Cook, C. J., Vance, B., Raleigh, S. M., Roberts, C., Bennett, M. A., Wang, G., Collins, M., Pitsiadis, Y. P. and Williams, A. G. (2016) Association of ACTN3 R577X but not ACE I/D gene variants with elite rugby union player status and playing position. Physiological Genomics. 48(3), pp. 196-201. 1531-2267.
  2. Rahim, M., El Khoury, L., Raleigh, S. M., Ribbans, W. J., Posthumus, M., Collins, M. and September, A. V. (2016) Human genetic variation, Sport and Exercise Medicine, and Achilles tendinopathy: role for angiogenesis-associated genes. OMICS: A Journal of Integrative Biology. 20(9), pp. 520-527. 1536-2310.
  3. El Khoury, L., Ribbans, W. J. and Raleigh, S. (2016) MMP3 and TIMP2 gene variants as predisposing factors for Achilles tendon pathologies: attempted replication study in a British case–control cohort. Meta Gene. 9, pp. 52-55. 2214-5400.
  4. Brown, K. L., Seale, K. B., El Khoury, L., Postthumus, M., Ribbans, W. J., Raleigh, S. M., Collins, M. and September, A. V. (2016) Polymorphisms within the COL5A1 gene and regulators of the extracellular matrix modify the risk of Achilles tendon pathology in a British case control study. Journal of Sports Sciences. 0264-0414. (In Press)
  5. Gibbon, A., Hobbs, H., Van der Merwe, W., Raleigh, S. M., Cook, J., Handley, C. J., Posthumus, M., Collins, M. and September, A. V. (2016) The MMP3 gene in musculoskeletal soft tissue injury risk profiling: a study in two independent sample groups. Journal of Sports Sciences. 0264-0414.

2015

  1. El Khoury, L., Posthumus, M., Collins, M., van der Merwe, W., Handley, C. J., Cook, J. and Raleigh, S. M. (2015) ELN and FBN2 gene variants as risk factors for two sports-related musculoskeletal injuries. International Journal of Sports Medicine. 36(4), pp. 333-337. 0172-4622.
  2. Rickaby, R., El Khoury, L., Ribbans, W. J. and Raleigh, S. M. (2015) Variation within three apoptosis associated genes as potential risk factors for Achilles tendinopathy in a British based case-control cohort. Gene. 571(2), pp. 167-171. 0378-1119.

2014

  1. El Khoury, L., Posthumus, M., Collins, M., Ribbans, W. J. and Raleigh, S. M. (2014) 82 The COL5A1 gene and risk of Achilles tendon pathology in a British cohort. British Journal of Sports Medicine. 48(Supp 2), A54. 0306-3674.
  2. El Khoury, L., Ribbans, W. J. and Raleigh, S. M. (2014) 84 TIMP2 and GDF-5 gene variants and achilles tendon pathology: replication study in a British case-control population. British Journal of Sports Medicine. 48(Supp 2), A55. 0306-3674.

2013

  1. El Khoury, L., Posthumus, M., Collins, M., Handley, C. J., Cook, J. and Raleigh, S. M. (2013) Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMT55, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology. Invited Presentation presented to: 18th Annual Congress of the European College of Sport Science (ECSS), Barcelona, Spain, 26-29 June 2013. (Unpublished)
  2. El Khoury, L., Posthumus, M., Collins, M., Handley, C. J., Cook, J. and Raleigh, S. M. (2013) Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: A genetic association study. Journal of Science and Medicine in Sport. 16(6), pp. 493-498. 1878-1861.
  3. Raleigh, S. M., Posthumus, M., O'Cuinneagain, D., van der Merwe, W. and Collins, M. (2013) The GDF5 gene and anterior cruciate ligament rupture. International Journal of Sports Medicine. 34(4), pp. 364-367. 0172-4622.
  4. Rickaby, R. and Raleigh, S. M. (2013) Variations within the COL5A1 and ADAM8 genes does not associate with Achilles tendon pathology. Invited Presentation presented to: 18th Annual Congress of the European College of Sport Science (ECSS), Barcelona, Spain, 26-29 June 2013. (Unpublished)

2012

  1. Raleigh, S. M. (2012) Epigenetic regulation of the ACE gene might be more relevant to endurance physiology than the I/D polymorphism. Journal of Applied Physiology. 112(6), pp. 1082-1083. 8750-7587 (print) 1522-1601 (online).
  2. Raleigh, S. M. and Collins, M. (2012) Gene variants that predispose to Achilles tendon injuries: an update on recent advances. In: Cretnik, A. (ed.) Achilles Tendon. Online: InTech. pp. 25-40.
  3. Raleigh, S. M. (2012) Last word on Viewpoint: Epigenetic regulation of the ACE gene might be more relevant to endurance physiology than the I/D polymorphism. Journal of Applied Physiology. 112(6), p. 1086. 8750-7587 (print) 1522-1601 (online).
  4. Posthumus, M., Collins, M., van der Merwe, L., O'Cuinneagain, D., van der Merwe, W., Ribbans, W. J., Schwellnus, M. P. and Raleigh, S. M. (2012) Matrix metalloproteinase genes on chromosome 11q22 and the risk of anterior cruciate ligament (ACL) rupture. Scandinavian Journal Of Medicine & Science In Sports. 22(4), pp. 523-533. 1600-0838 (online), 0905-7188 (print).
  5. El Khoury, L., Posthumus, M., Collins, M., Handley, C. J., Cook, J., Raleigh, S. M. and Ribbans, W. J. (2012) The Elastin and Fibrillin2 genes and the risk of Achilles tendon pathology. Poster presented to: XXXII International Federation of Sports Medicine (FIMS) World Congress of Sports Medicine, Rome, 27-30 September 2012. (Unpublished)

2011

  1. Posthumus, M., Collins, M., van der Merwe, L., O'Cuinneagain, D., van der Merwe, W., Ribbans, W. J., Schwellnus, M. P. and Raleigh, S. M. (2011) Matrix Metalloproteinase genes on chromosome 11q22 and the risk of anterior cruciate ligament (ACL) rupture. Invited Presentation presented to: International Olympic Committee (IOC) World Conference on Prevention of Injury & Illness in Sport, Grimaldi Forum, Monte Carlo, Monaco, 07–09 April 2011. Also presented at: 8th Biennial International Society of Arthroscopy, Knee Surgery & Orthopaedic Sports Medicine (ISAKOS) Congress, Rio de Janeiro, Brazil, 15-19 May 2011. (Unpublished)

2010

  1. Posthumus, M., Raleigh, S. M., Ribbans, W. J., Schwellnus, M. P. and Collins, M. (2010) A functional variant within the MMP3 gene does not associate with human range of motion. Journal of Science and Medicine in Sport. 13(6), pp. 630-632. 1440-2440.
  2. Posthumus, M., Collins, M., Cook, J., Handley, C. J., Ribbans, W. J., Smith, R. K., Schwellnus, M. P. and Raleigh, S. M. (2010) Components of the transforming growth factor-beta family and the pathogenesis of human Achilles tendon pathology--a genetic association study. Rheumatology. 49(11), pp. 2090-2097. 1462-0324.
  3. Raleigh, S. M. (2010) Possible epigenomic factors that might predispose to musculoskeletal soft tissue injury and pathology. Invited Presentation presented to: 4th Clinical Sports Medicine Conference: Injury Prevention and Protection of the Health of the Athlete, Cape Town, South Africa, 13-15 October 2010. (Unpublished)
  4. Raleigh, S. M. (2010) Sequence variation within the Matrix Metalloproteinase genes and predisposition to muscuskeletal soft tissue injury and pathology. Invited Presentation presented to: 4th Clinical Sports Medicine Conference: Injury Prevention and Protection of the Health of the Athlete, Cape Town, South Africa, 13-15 October 2010. (Unpublished)
  5. Posthumus, M., Collins, M., Cook, J., Handley, C. J., Ribbans, W. J., Smith, R. K. W., Schwellnus, M. P. and Raleigh, S. M. (2010) The GDF5 and TGFB1 genes and Achilles tendinopathy and Achilles tendon rupture. Invited Presentation presented to: International Scientific Tendinopathy Symposium, Umea, Sweden, 30 September - 01 October 2010. (Unpublished)
  6. Posthumus, M., Collins, M., van der Merwe, L., O'Cuinneagain, D., Ribbans, W. J., Schwellnus, M. P. and Raleigh, S. M. (2010) Variation within growth factor genes and the risk of anterior cruciate ligament (ACL) rupture. Invited Presentation presented to: 4th Clinical Sports Medicine Conference: Injury Prevention and Protection of the Health of the Athlete, Cape Town, South Africa, 13-15 October 2010. (Unpublished)

2009

  1. Collins, M. and Raleigh, S. M. (2009) Genetic risk factors for musculoskeletal soft tissue injuries. Medicine and Sports Science. 54, pp. 136-149. 0254-5020.
  2. Collins, M., Raleigh, S. M., van der Merwe, L., Ribbans, W. J., Smith, R. and Schwellnus, M. P. (2009) Variants within the MMP3 gene are associated with Achilles tendinopathy. Paper presented to: 13th Meeting of the South African Society for Human Genetics Conference, Stellenbosch, South Africa, 5-8 April 2009. (Unpublished)
  3. Raleigh, S. M., van der Merwe, L., Ribbans, W. J., Smith, R. K., Schwellnus, M. P. and Collins, M. (2009) Variants within the MMP3 gene are associated with achilles tendinopathy: possible interaction with the COL5A1 gene. British Journal of Sports Medicine. 43(7), pp. 514-520. 0306-3674.

2008

  1. Tobin, M. D., Tomaszewski, M., Braund, P., Hajat, C., Raleigh, S. M., Palmer, T. M., Caulfield, M., Burton, P. R. and Samani, N. J. (2008) Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population. Hypertension. 51(6), pp. 1658-1664. 1524-4563.
  2. Raleigh, S. M., Collins, M., van der Merwe, L., Ribbans, W. J., Smith, R. K. and Schwellnus, M. P. (2008) Variants within the MMP3 gene and Achilles tendinopathy. Invited Presentation presented to: XXX International Federation of Sports Medicine (FIMS) World Congress of Sports Medicine, Barcelona, 18-23 November 2008. (Unpublished)

2007

  1. Raleigh, S. M., Davies, B. M., Cleal, D. and Ribbans, W. J. (2007) No association between coding polymorphism within Exon 4 of the human surfactant protein B gene and pulmonary function in healthy men. Journal of Physiological Sciences. 57(3), pp. 199-202. 1880-6562.

2005

  1. Raleigh, S. M. (2005) A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study. The American Journal of Human Genetics. 77(6), pp. 1011-1020. 1537-6605.
  2. Tobin, M. D., Raleigh, S. M., Newhouse, S., Braund, P., Bodycote, C. L., Ogleby, J., Cross, D., Gracey, J., Hayes, S., Smith, T., Ridge, C., Caulfield, M., Sheehan, N. A., Munroe, P. B., Burton, P. R. and Samani, N. J. (2005) Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. Circulation. 112(22), pp. 3423-3429. 1524-4539.
  3. Vasa-Nicotera, M., Brouilette, S., Mangino, M., Thompson, J. R., Braund, P., Clemitson, J.-R., Mason, A., Bodycote, C. L., Raleigh, S. M., Louis, E. and Samani, N. J. (2005) Mapping of a major locus that determines telomere length in humans. American Journal of Human Genetics. 76(1), pp. 147-151. 1537-6605.

2004

  1. Tobin, M. D., Sheehan, N. A., Raleigh, S. M., Samani, N. J. and Burton, P. R. (2004) Characterising phenotype in genetic studies of blood pressure. Invited Presentation presented to: American Society of Human Genetics (ASHG) Annual Meeting, Toronto, Canada, 2004. (Unpublished)

2000

  1. Raleigh, S. M., Verschoyle, R. D., Bowskill, C., Pastorino, U., Staniforth, J. N., Steele, F., Dinsdale, D., Carthew, P., Lim, C. K., Silvester, J. and Gescher, A. (2000) Pulmonary availability of isotretinoin in rats after inhalation of a powder aerosol. British Journal of Cancer. 83(7), pp. 935-940. 0007-0920.

1999

  1. Patterson, L. H., McKeown, S. R., Robson, T., Gallagher, R., Raleigh, S. M. and Orr, S. (1999) Antitumour prodrug development using cytochrome P450 (CYP) mediated activation. Anti-Cancer Drug Design. 14(6), pp. 473-486. 0266-9536.
  2. Raleigh, S. M., Wanogho, E., Burke, M. D. and Patterson, L. H. (1999) Rat cytochromes P450 (CYP) specifically contribute to the reductive bioactivation of AQ4N, an alkylaminoanthraquinone-di-N-oxide anticancer prodrug. Xenobiotica. 29(11), pp. 1115-1122. 0049-8254.

1998

  1. Raleigh, S. M., Wanogho, E., Burke, M. D., McKeown, S. R. and Patterson, L. H. (1998) Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug. International Journal of Radiation Oncology, Biology, Physics. 42(4), pp. 763-767. 0360-3016.
  2. Patterson, L. H. and Raleigh, S. M. (1998) Reductive metabolism: its application in prodrug activation. In: Gooderham, N. J. (ed.) Drug Metabolism: Towards the Next Millenium. Amsterdam: IOS Press. pp. 72-80.

1993

  1. Padgham, C. R., Boyle, C. C., Wang, X. J., Raleigh, S. M., Wright, M. C. and Paine, A. J. (1993) Alteration of transcription factor mRNAs during the isolation and culture of rat hepatocytes suggests the activation of a proliferative mode underlies their de-differentiation. Biochemical and Biophysical Research Communications. 197(2), pp. 599-605. 0006-291X.
This list was generated from NECTAR on Tue Dec 6 15:07:28 2016 GMT.

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